2-B-P-054 〇加納 誠一朗、仲田 勝哉、渋谷 優斗、高橋 空雅、永井 宏季、船木 晴登、松川 妃奈 Seiichiro Kano, Katsuya Nakata, Yuto Shibuya, Kuga Takahashi, Hiroki Nagai, Haruto Funaki, Hina Matsukawa 北海道科学大・薬 Dept. of Life Science Hokkaido Univ. of Science This study aimed to investigate the effects of adrenaline treatment on abnormal electrical signals in the ECG of anaphylaxis-induced rats. Wistar male rats were anesthetized, ventilated, and placed on a multi-electrode probe array at the heart to record the ECG and measure blood pressure. Anaphylaxis was induced with compound 48/80, and saline or adrenaline was injected intravenously 15 minutes after anaphylaxis and observed until 30 minutes after anaphylactic induction. Hypotension associated with anaphylactic shock was transiently recovered by adrenaline administration. QTc shortening was observed during anaphylaxis induction and transiently improved with adrenaline administration. The frequency of PVCs increased during anaphylaxis induction and decreased with adrenaline administration. Although there was no difference in the expression of gap junction protein Connexin40 protein in myocardial tissue at 30 minutes of anaphylaxis induction in the adrenaline-treated group compared with the untreated group, H-FABP protein expression in myocardial tissue was significantly lower in the adrenaline-treated group. Thus, the reduction in QTc shortening and PVC frequency with adrenaline administration during anaphylaxis induction may be associated with a decrease in H-FABP protein expression in myocardial tissue.