3-B-P-036 〇佐々木 一暁、大塚 康之、赤星 洋彦、守住 孝輔、片山 誠一、廣中 直行、西 勝英 Kazuaki Sasaki, Yasuyuki Otsuka, Hirohiko Akahoshi, Kousuke Morizumi, Seiichi Katayama, Naoyuki Hironaka, Katsuhide Nishi メディフォード（株）（旧（株）ＬＳＩＭ安全科学研究所） Mediford Corporation The number of potential fecal incontinence patient in Japan is estimated to be about 5 million, but no fundamental treatment has been developed so far. Therefore, development of new treatments and/or novel drugs is expected. Screening using animal models is important for development of new therapeutic agents. In the previous studies, we have developed a method of measuring the contractile activity of the internal anal sphincter (IAS) in unanesthetized, unrestrained dogs by placing a force transducer into the IAS, and acquiring the the contractile activity using a telemetry method. These studies were reported at the 91st and 92nd Annual Meeting of the Japanese Pharmacological Society. In the present study, we developed a method for measuring the IAS contractile activity in dogs under sedation. The dog fecal incontinence model was created by impairing IAS. The contractile activity was measured by manometry using a pressure sensor catheter. By periodically measuring the IAS contractile activity before and after the model creation, we obtained basic data of the contractile activity during the process of spontaneous healing. In addition, we also report the effects of comparative control substances, phenylephrine in this model, for the future evaluation of the efficacy of new drugs.