Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for COVID-19, continues to spread around the world and has caused millions of deaths to date. In an effort to develop therapeutics and preventive measures, we are performing numerous research projects with this virus and its variants. In this presentation, I will discuss our findings regarding animal models and their value as tools for evaluating countermeasures against SARS-CoV-2.