Histamine within the central nervous system is a promising target for reactivating forgotten memories. We have previously demonstrated that histamine H₃ receptor inverse agonists enhance histamine release in the perirhinal cortex (PRh) and facilitate retrieval of forgotten object memories. Nevertheless, considering that histamine H₃ receptors are expressed in non-histaminergic neurons as well, it is plausible that other neurotransmitter systems might also be involved in memory recovery. This study directly tested the contribution of central histamine signaling to retrieval recovery. We virally targeted hM3Dq, the Gq-coupled excitatory designer receptor exclusively activated by designer drugs (DREADD), to histaminergic neurons in the tuberomammillary nucleus of HDC-Cre mice. One week after the training session of the novel object recognition task, mice underwent a test session where one familiar and one novel objects were presented. The pre-test injection of clozapine-N-oxide to the mice receiving AAV-DIO-hM3Dq increased discrimination between novel and familiar objects, indicating enhanced memory retrieval. This effect was blocked by intra-PRh infusions of ranitidine, a histamine H₂ receptor antagonist. These results indicate that chemogenetic activation of histamine neurons promotes memory retrieval through PRh H₂ receptor activation.