[Background]Atherosclerosis results from vascular endothelial cell injury caused by lipid metabolites deposition in the vessel wall, leading to myocardial and cerebral stroke. Early detection and treatment are difficult because of the lack of clinical symptoms in the early stages. MicroRNAs (miRNAs) regulate the expression of target mRNAs and have attracted attention as diagnostic biomarkers. In this study, we focused on the adhesion between monocytes and endothelial cells in the early stage of atherosclerosis. We examined the relationship between miRNAs and changes in endothelial-monocyte adhesion induced by IL-1β. 
[Results]We found that hsa-miR-1914-5p was decreased by IL-1β stimulation in human vascular endothelial cell line EA.hy926 or monocytic cell line THP-1. Endothelial-monocyte adhesion and expression of adhesion factors were significantly increased under both IL-1β-stimulated and hsa-miR-1914-5p inhibitory conditions. Furthermore, overexpression of hsa-miR-1914-5p significantly suppressed IL-1β-induced adhesion. 
[Conclusion] These results suggest that hsa-miR-1914-5p may suppress endothelial-monocyte adhesion, thereby reducing the progression of early lesions in atherosclerosis. These findings are expected to lead to the development of novel therapies for atherosclerosis targeting hsa-miR-1914-5p as well as its application as a biomarker.