The Pre-Disease Database, conceived under the aegis of Moonshot Goal 2's Aihara Projects, aims to revolutionize research data management. This lecture will provide a comprehensive examination of the database's intrinsic functionalities, real-world applications, and future trajectory. The database operates on two distinct yet complementary platforms: GakuNin RDM for data management, and JAIRO Cloud for data dissemination. GakuNin RDM serves as the managerial platform, equipped with advanced data analysis features. It permits seamless integration with various computational resources, including supercomputers, High-Performance Computing (HPC), and mdx platforms. Additionally, its provenance management assures accurate traceability of the data lineage. Concurrently, JAIRO Cloud functions as the public platform, offering an unmatched level of flexibility for user interface (UI) and metadata customization. It also collaborates with international scholarly communication networks. This lecture, in the context of Moonshot Goal 2, will showcase how the Pre-Disease Database fosters efficient data sharing and utilization among multiple projects. The lecture aims to engage physicians, pharmaceutical researchers, and healthcare organizations in a substantive dialogue regarding the database's potential utility, strategic implementation, and prospective developments, while also addressing its anticipated societal and academic impacts.