Cell membranes are composed of diverse phospholipid molecules, whose structure and distribution are actively controlled in response to various stresses. Furthermore, the structure and distribution of phospholipid molecules influence the physicochemical properties of membranes and affect the activity of a variety of membrane proteins including ion channels and receptors. Therefore, membrane phospholipids can be considered to be the determinants of cellular resilience. We used Drosophila cells in which the phospholipid composition and regulatory mechanisms are relatively simple, to understand the molecular mechanism underlying the membrane phospholipid-mediated control of cellular resilience against temperature change and mechanical stimuli. In this presentation, I would like to introduce the flexible cellular responses mediated by the dynamic regulation of membrane phospholipids in Drosophila cells.