Purpose:Cellular senescence is a state of irreversible cell-cycle arrest, proinflammatory cytokine secretion, and mitochondrial dysfunction that contributes to liver disease progression. Taurine, a naturally occurring amino acid with antioxidative and cytoprotective properties, has beneficial effects in liver damage models. A recent study has found that daily taurine intake reduced cellular senescence in aged rodents. In the present study, we investigated the potential of taurine to ameliorate Carbon tetrachloride- (CCL4-) induced liver injury and its impact on cellular senescence. To assess the therapeutic efficacy of taurine on mice liver injury, hepatic malondialdehyde (MDA) level together with morphological alterations, and cellular senescence expression in the liver following CCL4 administration were investigated.Methods: The animals were divided into three groups.C57BL/6 mice were intraperitoneally injected with CCL4 dissolved in olive oil (2ml/kg) twice per week for 8 weeks. Taurine treated animals received 3% taurine solution by the drinking water from the 4 weeks of the carbon tetrachloride treatment. Control animals received same amount of olive oil.Results: CCL4 administration increased liver weight, decreased body weight and increased liver MDA concentration. The increases of MDA concentration were attenuated by taurine treatment. The morphological changes in the CCL4 group included discoloration of liver, scaring in the tissue, irregular edges and dysplastic nodule, which were slightly ameliorated by taurine treatment. Taurine treatment attenuated the CCL4-induced increase in hepatic p21, a senescence associated marker. Furthermore, we will also evaluate the hepatic fibrosis induced by the chronic exposure of CCL4.Conclusion:These results suggest that taurine treatment might significantly changes the oxidative parameters and reduced the rise in hepatic p21 expression caused by CCL4.