Background＆Aim: Oral bacteria potentially affect the provocation or the disease state of various systemic diseases. In our present study, we examined relationship between cardiovascular diseases and microbiome or detection rates of pathogenic oral bacteria.
Method: Patients of atrial fibrillation (AF), angina pectoris (AP), aortic stenosis (AS) and healthy control volunteers were recruited. Subjects washed their mouse with distilled water and regurgitated it as bacterial samples. Extracted bacterial DNA was sequenced to analyze microbiome of each group. Besides, Porphyromonas gingivalis (P.g), Streptococcus mutans (S.m) and S.m-derived collagen-binding protein (cnm), through which S.m induces dysfunction of tissues or organs were detected by PCR. Percentages of bacteria in microbiome and detection rates of P.g and S.m were compared between groups. In addition, we also examined correlation between these percentages and rates and serum values of IL-6 and CRP which are indicators of the disease state. 
Resutls: The number of patients with S.m was greater in the AF and AP groups compared to that in the group of healthy subjects. Especially, number of cnm-positive subjects was larger in AP group, that positively correlates serum IL-6 levels. Furthermore, there was a positive correlation between P.g infection and the presence of AP. On the contrary, significant correlation was not observed between these bacteria and the presence of AS. However, only AS but not AF and AP exhibited elevated percentages of Gemella genus, that was positively correlated with serum CRP levels. 
Conclusion: Characteristic microbiome or infection pattern could be observed in each cardiovascular disease, that may be responsible for disease state.