We recently reported that blindness impairs sleep quality in mice (Iba et al. Biol Pharm Bull. 2023). Albinism is also known to cause visual impairment. In the present study, we compared locomotor activity and delayed recovery from general anesthesia induced by hypnotics during light and dark periods in pigmented C57BL/6N (B6N) and albino (B6-Albino) mice. There were no significant differences in locomotor activity between B6N and B6-Albino mice during the light and dark periods. Brotizolam significantly delayed recovery from isoflurane anesthesia in both periods in B6N mice and the dark period in B6N-Albino mice. The delayed recovery was more pronounced in the light than in the dark period in B6N mice but was similar in both periods in B6-Albino mice. Diphenhydramine delayed recovery from isoflurane anesthesia, albeit slightly, in the dark period in B6N mice and the light period in B6-Albino mice. Suvorexant delayed recovery from anesthesia induced by a mixture of medetomidine, midazolam, and butorphanol (MMB) in B6N and B6-Albino mice only in the light period. However, unexpectedly, B6-albino mice recovered from MMB anesthesia significantly faster than B6N mice in the dark period. These results indicate that sleep quality is impaired in albino mice.