Anticancer drugs are most commonly administered via transvenous administration. However, the most serious local complication is extravasation because even a non-vesicant leak can cause inflammation of the vessel and surrounding tissue, narrowing of the vessel, and pathologic hardening of the surrounding tissue. Inflammatory findings such as thrombus and edema at the injection site are detected by subcutaneous observation using an ultrasound device immediately after treatment in the outpatient chemotherapy room, indicating that these findings were associated with the induration of delayed adverse events. To prevent extravasation and induration, the vessel wall must be preserved. Therefore, we aimed to minimize the stimulation of the vessel wall by administering drugs using a peripheral intravenous catheter. We observed that vessels can be preserved by using catheters made of soft materials, placing them in veins with large diameters, and inserting them in a single attempt. The effect of vessel preservation via catheter placement that meets these requirements will be presented.