In the development of drug discovery for atopic dermatitis（AD）, chemical-induced, special diet-induced or Tg mice have been used in experiments using rodents.
In order to overcome AD, it is expected that an animal model that appropriately reproduces the pathological condition of human AD can be created and utilized for pathological analysis and drug discovery research.
IL-33 is known to induce inflammatory cytokines or increase eosinophils by signaling from the nuclear transcription factor NFkB.
In the clinical picture of AD, it has been reported that IL-33 is highly expressed in human skin.
The model overproduces IL-33 in mice skin, induces inflammatory mediators via signaling from nuclear transcription factors, and results in Th2-dominant predominance, leading to AD.
In this presentation, introduce phenotypes such as itching behavior and histological examination of IL-33Tg mice.