Recent evidence shows that the primary visual cortex (V1) is plastic and associated with storage of visual long-term memory. Although the hippocampal formation is not monosynaptically connected with the V1, neuronal activity of the V1 is modulated during hippocampal ripples, a form of 150-250 Hz oscillations that plays a role in memory consolidation, and the modulation may contribute to memory formation and retention; however, little is known about subthreshold activity in individual V1 neurons during hippocampal ripples. We recorded membrane potentials (Vms) from V1 layer Ⅱ/Ⅲ pyramidal cells of urethane-anesthetized mice using the whole-cell current-clamp technique, together with recording local field potentials (LFPs) from the hippocampal CA1 region, to explore the Vm fluctuations in V1 neurons in response to hippocampal ripples. Time series analyses of hippocampal LFPs and V1 neuronal Vm revealed a significant portion of V1 neurons are briefly depolarized after the ripple onsets when they are at DOWN states of the Vm slow oscillations, whereas V1 neurons exhibited a variety of responses (or no responses) after hippocampal ripples at the UP states. The latencies of the depolarizations at DOWN states relative to the ripple onsets ranged from 20 to 40 ms, suggesting multisynaptic transmission from the hippocampus to the V1. Our findings advance our understanding about the neuronal mechanisms underlying neocortical consolidation of visually relevant memories.