Oxidative stress plays a key role in several diseases including neurodegenerative diseases. The nuclear factor erythroid 2-related factor 2-antioxidant response element (Nrf2-ARE) pathway is a cellular defense mechanism against oxidative stress by upregulating cytoprotective genes and enzymes. Based on this idea, the Nrf2-ARE pathway has emerged as a therapeutic target for neuroprotection from neurodegenerative diseases. In fact, clinical application of Nrf2 activators has been implemented against multiple sclerosis. Searches are still underway for new, highly active and safe Nrf2 activators. Nrf2 activators derived from fruits and vegetables with eating experience may be advantageous for social implementation. Of course, screening of chemical libraries conducted by pharmaceutical companies is also effective in finding lead compounds. In this presentation, I would like to introduce our uniquely identified Nrf2 activator and its pharmacological effects in the experimental Parkinson disease models.