Up to now, there is no effective therapy for aged-related dementia. Well-balanced dietary pattern and nutrition is one of the beneficial factors for preventing cognitive impairment. On the other hand, Coriandrum sativum (C. sativum) , commonly known as coriander belonging to the family Apiaceae (Umbelliferae) contains bioactive phytochemicals that are accounted for a wide range of biological activities including antioxidant, anticancer, neuroprotective, anxiolytic, anticonvulsant, analgesic, migraine-relieving, hypolipidemic, hypoglycemic, hypotensive, anti-microbial, and anti-inflammatory activities. Antioxidant activity of C. sativum serves as a key mechanism for protection against neuronal oxidative damages. Anti-inflammatory property also plays roles in migraine-relieving effect as well as in prevention of brain chronic inflammation. There are several studies demonstrated that the extract of C. sativum leaves and seeds improved memory and learning abilities in Wistar rats and accelerated aging model (SAMP8, senescence accelerated mouse-prone 8). Therefore, C. sativum may be a potential functional food or a medicinal herb for preventing cognitive impairment.